MRCP UK EXAMINATIONS

Detailed explanation-1: -Stasis dermatitis can affect the feet or lower legs on one or both sides. It can appear on other parts of the body, but this is uncommon. Besides ankle swelling, early signs include orange-brown speckles of discoloration sometimes called cayenne pepper spots.

Detailed explanation-2: -Stasis dermatitis is caused by venous hypertension resulting from retrograde flow related to incompetent venous valves, valve destruction, or obstruction of the venous system. The ensuing inflammatory process is mediated by metalloproteinases, which are up-regulated by ferric ion from extravasated red blood.

Detailed explanation-3: -Stasis dermatitis, or stasis eczema, is a common inflammatory dermatosis of the lower extremities occurring in patients with chronic venous insufficiency, often in association with varicose veins, dependent chronic edema, hyperpigmentation, lipodermatosclerosis, and ulcerations (picture 1A-B).