MRCP UK EXAMINATIONS

Detailed explanation-1: -IL-17A and IL-17F are primarily involved in the pathogenesis of psoriasis, but IL-17C and IL-17E are also implicated in the disease state. Furthermore, the expression of these four cytokines is increased within psoriatic skin lesions, supporting their role in psoriasis.

Detailed explanation-2: -IL-17 and IL-23 have unique mechanisms of action in PsO immunopathogenesis, with IL-17 being an important cytokine in the PsO inflammatory cascade. New biologic agents blocking IL-17A and/or IL-23 are more efficacious than traditional biologic therapies that are less specific in targeting the psoriatic disease process.

Detailed explanation-3: -In summary, the IL-23/T17 signaling pathway is central to the immunopathogenesis of psoriasis by stimulating the proliferation of IL-17-producing lymphocytes and sustaining the inflammatory milieu found in psoriatic plaques.