CLINICAL ENCOUNTERS
RHEUMATOID ARTHRITIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Block prostaglandin synthesis by the COX-2 isozyme
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Does not affect action of COX-1 isozyme
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Anti-inflammatory
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Affects action of COX-1 isozyme
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Detailed explanation-1: -What are COX-2 inhibitors? COX-2 inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAIDs). NSAIDs relieve pain and fever and reduce inflammation. Examples of older traditional NSAIDs include ibuprofen (Advil®, Motrin®) and naproxen (Aleve®).
Detailed explanation-2: -COX-2 selective inhibitors were developed to reduce the risk of gastrointestinal ulceration caused by non-selective NSAIDs. By selectively inhibiting COX-2 they reduced the risk of upper gastrointestinal bleeding associated with other NSAIDs.
Detailed explanation-3: -Mechanism of action Selective COX-2 inhibitors do not affect platelet TXA2 production and therefore do not directly impair platelet aggregation. However, they suppress the production of the antiaggregatory and vasodilator PGI2 by blood vessels, which may allow TXA2 to exert unopposed aggregatory effects on platelets.