MRCP UK EXAMINATIONS

Detailed explanation-1: -Tumor necrosis factor (TNF) is a central cytokine in inflammation and an important therapeutic target in dermatology. For reasons unknown, TNF is still referred to as TNF- in numerous newly published scientific papers, almost 2 decades after the cytokine was renamed.

Detailed explanation-2: -Role of TNF in Inflammation. TNF is a powerful pro-inflammatory agent that regulates many facets of macrophage function. It is rapidly released after trauma, infection, or exposure to bacterial-derived LPS and has been shown to be one of the most abundant early mediators in inflamed tissue.

Detailed explanation-3: -TNF inhibitors are drugs that help stop inflammation and are used worldwide to treat inflammatory conditions such as rheumatoid arthritis (RA), psoriatic arthritis, juvenile idiopathic arthritis, inflammatory bowel disease (Crohn’s and ulcerative colitis), ankylosing spondylitis, and psoriasis.