CLINICAL ENCOUNTERS
RHEUMATOID ARTHRITIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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HLA-DRB3
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HLA-A
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HLA-DP1
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HLA-DRB1
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Detailed explanation-1: -HLA alleles and susceptibility to rheumatoid arthritis-Both linkage and association studies have established that the human leukocyte antigen (HLA) DRB1 gene is the major genetic susceptibility locus for rheumatoid arthritis (RA).
Detailed explanation-2: -HLA-DR4-This is the gene that is most associated with RA. People who have this gene are more likely to develop RA than those who do not and symptoms may be worse. STAT4-This particular gene regulates and activates the immune system.
Detailed explanation-3: -Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules.
Detailed explanation-4: -HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) is a Protein Coding gene.