MRCP UK EXAMINATIONS

CLINICAL ENCOUNTERS

SYSTEMIC SCLEROSIS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What is the immunosuppressive treatment for TC?
A
non-selective
B
Affect T cells
C
Affect B cells
D
biological
E
intravenous immunoglobulin
Explanation: 

Detailed explanation-1: -Exerts immunosuppressive action by suppressing the proliferation of B-lymphocytes and, thus, modulation of antibody production. [53] IVIG can also induce suppression of autoreactive B lymphocytes and neutralization of their cytokines.

Detailed explanation-2: -Ig replacement therapy is generally administered either intravenously (abbreviated IVIG), or subcutaneously (abbreviated SCIG). SCIG can be given in two ways: conventional or facilitated.

Detailed explanation-3: -Context Intravenous immunoglobulin (IVIG) enhances immune homeostasis by modulating expression and function of Fc receptors, interfering with activation of complement and production of cytokines, providing anti-idiotypic antibodies, and affecting the activation and effector functions of T and B cells.

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