MRCP UK EXAMINATIONS

Detailed explanation-1: -Edrophonium is a reversible acetylcholinesterase inhibitor with rapid onset and short duration of action resulting in an increase of acetylcholine in the neuromuscular junction (NMJ). [1] Since the early 1930s, it has been a diagnostic tool for myasthenia gravis (MG).

Detailed explanation-2: -A Tensilon test is a diagnostic test used to evaluate myasthenia gravis, which is a neuromuscular condition characterized by muscle weakness. The test involves an injection of Tensilon (edrophonium), after which your muscle strength is evaluated to determine whether your weakness is caused by myasthenia gravis or not.

Detailed explanation-3: -Atropine is an effective antidote to the muscarinic side effects of edrophonium chloride but does not counteract the nicotinic effects on the motor endplate that result in paralysis of the skeletal muscles.

Detailed explanation-4: -In myasthenia gravis, your immune system produces antibodies that block or destroy many of your muscles’ receptor sites for a neurotransmitter called acetylcholine (as-uh-teel-KOH-leen). With fewer receptor sites available, your muscles receive fewer nerve signals, resulting in weakness.