MRCP UK EXAMINATIONS

Detailed explanation-1: -Studies have shown that symptoms of Parkinson’s develop in patients with an 80 percent or greater loss of dopamine-producing cells in the substantia nigra. Normally, dopamine operates in a delicate balance with other neurotransmitters to help coordinate the millions of nerve and muscle cells involved in movement.

Detailed explanation-2: -Abstract. Parkinson’s disease is characterized by a deficiency of dopamine in the nigrostriatal system. However, changes in dopamine neurons were found also outside the extrapyramidal system, showing that there is a more general brain defect than just the loss of substantia nigra dopamine neurons.

Detailed explanation-3: -Parkinson’s Progression May Be Tied to Imbalance in Dopamine and Acetylcholine Levels, Study Says.

Detailed explanation-4: -The loss of midbrain dopamine in Parkinson’s disease is accompanied by a matching loss in the dopamine transporter and a rise in the D1 and D2 receptor densities. This is found in the brain putamen and caudate tissues from unmedicated patients, and may account for the good early clinical response to L-dopa.