NEUROLOGY
MONONEUROPATHIES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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About ALS
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it affects only the striated muscles
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it comes in 2 forms:bulbar and spinal
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there is amyotrophy, fasciculations and motor deficit
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ROTs are abolished
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riluzole is the only ET having proven its effectiveness on survival
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Explanation:
Detailed explanation-1: -Riluzole, a glutamatergic antagonist, is the only disease-modifying treatment shown to extend life in patients with ALS, associated with a 38·6% reduction in mortality in an efficacy trial9 and a 35% improvement in survival with the 100 mg dose in a dose-ranging trial.
Detailed explanation-2: -The original analyses, and subsequent meta-analyses, of data obtained from randomized controlled trials (RCTs) suggest that riluzole typically extends survival by 2–3 months and increases the chance of an additional year of survival by 9%.
Detailed explanation-3: -Riluzole may slow progression of ALS but does not cure it.
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