MRCP UK EXAMINATIONS

Detailed explanation-1: -The most common cause of distal axonopathy is diabetes, and the most common distal axonopathy is diabetic neuropathy. The most distal portions of axons are usually the first to degenerate, and axonal atrophy advances slowly towards the nerve’s cell body.

Detailed explanation-2: -During the onset of neurodegenerative diseases, axon degeneration occurs before the neuronal cell body undergoes apoptosis. The degeneration of axons separates the neurons from their targets, therefore inducing the loss of neuronal function.