NEUROLOGY
MONONEUROPATHIES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The substance / group needed to convert Homocysteine into Methionine (this group is provided by Methycobal) is____
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Gugus Methyl
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Gugus Hidroxyl
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Phenol group
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Carbonyl Glucose
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Explanation:
Detailed explanation-1: -Methionine synthase is known to promote methyl group transfer from methylated folate to homocysteine to yield methionine. This reaction is supported by cobalamin as a cofactor in methionine synthase. During this catalytic reaction, there are two key intermediates, nucleophilic cobalt(I) and methylated cobalamin.
Detailed explanation-2: -Activated homocysteine is attached to initiator tRNA and then converted to methionine by a methylating enzyme. In the absence of methylation, tRNA-attached homocysteine is hydrolysed to produce homocysteine thiolactone.
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