MRCP UK EXAMINATIONS

Detailed explanation-1: -Nerve injury triggers the conversion of myelin and non‐myelin (Remak) Schwann cells to a cell phenotype specialized to promote repair. Distal to damage, these repair Schwann cells provide the necessary signals and spatial cues for the survival of injured neurons, axonal regeneration and target reinnervation.

Detailed explanation-2: -Schwann cells play a key role in peripheral nerve repair after acute nerve injury. In case of nerve transection, SC migrate into the bridge area between proximal and distal nerve stumps. In the bridge, SC interact with fibroblasts, macrophages and blood vessels to facilitate axonal regrowth.