NEUROLOGY
PARKINSON S DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Can dopamine cross the bloodbrain barrier
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Yes
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No
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Either A or B
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None of the above
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Explanation:
Detailed explanation-1: -Dopamine (DA) is a cell-signaling molecule that does not readily cross the blood-brain barrier.
Detailed explanation-2: -Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson’s disease.
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