MRCP UK EXAMINATIONS

NEUROLOGY

PARKINSON S DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
How do medications designed to treat Alzheimer’s disease work?
A
They replace levels of serotonin in the brain
B
They prevent acetylcholine from being broken down in the brain.
C
They cure Alzheimer’s disease by restoring memory functioning.
D
They prevent levels of acetylcholine from breaking down and replace depleted levels of acetylcholine.
Explanation: 

Detailed explanation-1: -Donepezil, rivastigmine and galantamine all prevent an enzyme called acetylcholinesterase from breaking down acetylcholine. This means there is a higher concentration of acetylcholine in the brain, which leads to better communication between nerve cells. This may ease some symptoms of Alzheimer’s disease for a while.

Detailed explanation-2: -Cholinesterase inhibitors prevent the breakdown of acetylcholine, a brain chemical believed to be important for memory and thinking. As Alzheimer’s progresses, the brain produces less acetylcholine and, over time, these medicines eventually lose their effectiveness.

Detailed explanation-3: -Acetylcholine (ACh), a neurotransmitter essential for processing memory and learning, is decreased in both concentration and function in patients with Alzheimer’s disease.

There is 1 question to complete.