MRCP UK EXAMINATIONS

Detailed explanation-1: -The most prominent signs and symptoms of Parkinson’s disease occur when nerve cells in the basal ganglia, an area of the brain that controls movement, become impaired and/or die. Normally, these nerve cells, or neurons, produce an important brain chemical known as dopamine.

Detailed explanation-2: -Parkinson’s disease is a condition where a part of your brain deteriorates, causing more severe symptoms over time. While this condition is best known for how it affects muscle control, balance and movement, it can also cause a wide range of other effects on your senses, thinking ability, mental health and more.

Detailed explanation-3: -Although Parkinson’s disease (PD) primarily affects the central nervous system, it is a multi-organ disease which also affects the eyes and the peripheral nervous system, including the autonomic fibers (1, 2). PD-related disturbance of the peripheral nerves may result in sensory, motor, or autonomic neuropathy.

Detailed explanation-4: -In PD, the pathogenesis affects both parasympathetic and sympathetic nerve activity, which in turn seems to mediate the abnormal cardiovascular responses observed during exercise.