MRCP UK EXAMINATIONS

Detailed explanation-1: -Parkinson’s disease is a progressive disorder that is caused by degeneration of nerve cells in the part of the brain called the substantia nigra, which controls movement. These nerve cells die or become impaired, losing the ability to produce an important chemical called dopamine.

Detailed explanation-2: -Parkinson’s disease is caused by a loss of nerve cells in the part of the brain called the substantia nigra. Nerve cells in this part of the brain are responsible for producing a chemical called dopamine.

Detailed explanation-3: -Heart failure related to RAS hyperactivity and cardiac inflammation cause the degeneration of dopaminergic neurons. Taken together, metabolic alterations could affect dopaminergic neuronal loss and degeneration, leading to PD neuropathology including motor disturbance and cognitive decline.

Detailed explanation-4: -The most prominent signs and symptoms of Parkinson’s disease occur when nerve cells in the basal ganglia, an area of the brain that controls movement, become impaired and/or die. Normally, these nerve cells, or neurons, produce an important brain chemical known as dopamine.