MRCP UK EXAMINATIONS

Detailed explanation-1: -Alpha-lipoic acid seems to delay or reverse peripheral diabetic neuropathy through its multiple antioxidant properties. Treatment with alpha-lipoic acid increases reduced glutathione, an important endogenous antioxidant. In clinical trials, 600 mg alpha-lipoic acid has been shown to improve neuropathic deficits.

Detailed explanation-2: -Alpha-lipoic acid can significantly increase the cellular capacity of GSH synthesis by inducing of nuclear factor erythroid 2-related factor 2 (Nrf-2)-mediated antioxidant gene expression. ALA activates 5′-AMP-activated protein kinase (AMPK) and inhibits NF-B, which in turn have a plethora of metabolic consequences.

Detailed explanation-3: -Alpha-lipoic acid is a medication used to manage and treat chronic diseases associated with oxidative stress, such as diabetic neuropathy, and slow down the onset of metabolic syndrome by acting as an antioxidant.

Detailed explanation-4: -Studies also found that alpha-lipoic acid supplements can help with neuropathy–nerve damage–caused by diabetes or cancer treatment. They seem to reduce symptoms like pain, tingling, and prickling in the feet and legs.