MRCP UK EXAMINATIONS

Detailed explanation-1: -Therefore, in response to damage, both neurons and Schwann cells convert to cell states that are specialized to deal with injury and promote healing. Comparable reprogramming of differentiated cells in response to injury can also be seen in other systems.

Detailed explanation-2: -Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials.

Detailed explanation-3: -In the distal stump, denervated Schwann cells convert to a repair supportive phenotype. These repair (Bungner) Schwann cells form regeneration tracks (Bungner bands; dark blue cells) that guide regenerating axons back to their targets and provide essential trophic support for injured neurons.

Detailed explanation-4: -Nerve injury triggers the conversion of myelin and non‐myelin (Remak) Schwann cells to a cell phenotype specialized to promote repair. Distal to damage, these repair Schwann cells provide the necessary signals and spatial cues for the survival of injured neurons, axonal regeneration and target reinnervation.