MRCP UK EXAMINATIONS

Detailed explanation-1: -A breakdown in the blood-brain barrier (BBB) is thought to be an early stage in this process. If the BBB is damaged or weakened in some way, immune cells are able to cross. These cells then attack the myelin around your nerves, which leads to nerve damage and MS symptoms.

Detailed explanation-2: -The blood–brain barrier restricts the passage of pathogens, the diffusion of solutes in the blood, and large or hydrophilic molecules into the cerebrospinal fluid, while allowing the diffusion of hydrophobic molecules (O2, CO2, hormones) and small non-polar molecules.

Detailed explanation-3: -The key difference between blood brain barrier and blood CSF barrier is that blood brain barrier is the barrier which separates the blood tissue and the brain tissue while the blood CSF barrier is a functional barrier which separates the blood tissue and the cerebrospinal fluid.

Detailed explanation-4: -The remaining CSF is derived from the interstitial fluid of the brain which is produced by the BBB and the ependymal cells lining the ventricles [18, 24, 25, 26]. The total volume of CSF in humans is about 140 ml, and every day about 600 ml CSF is produced [27].