MRCP UK EXAMINATIONS

Detailed explanation-1: -metformin can commonly reduce vitamin B12 levels in patients, which may lead to vitamin B12 deficiency. the risk of low vitamin B12 levels increases with higher metformin dose, longer treatment duration, and in patients with risk factors for vitamin B12 deficiency.

Detailed explanation-2: -“Our results show that metformin doesn’t lead to vitamin D deficiency.”

Detailed explanation-3: -B-12 deficiency can also lead to peripheral neuropathy with symptoms that may include numbness, weakness, pain, and paresthesia (a burning or itchy sensation of the skin). It’s usually felt on the arms, hands, legs, and feet. Some people experience numbness, tingling, or a prickly feeling.

Detailed explanation-4: -This study concluded that the prevalence of vitamin B12 deficiency in T2DM patients using metformin was about 17.5%, and the risk of developing metformin-induced vitamin B12 deficiency might increase with longer metformin use. Moreover, vitamin B12 deficiency is influenced by the occurrence and duration of diabetes.