MRCP UK EXAMINATIONS

Detailed explanation-1: -As an auxiliary agent, it exerts neuronal protection by promoting regeneration of injured nerves and antagonizing glutamate-induced neurotoxicity.

Detailed explanation-2: -Vitamin B12 is known as a redox-active cofactor and it functions as an ROS scavenger [30]. It reduces oxidative stress in the cytosol and mitochondria; thus, it prevents cellular death [31].

Detailed explanation-3: -Application of vitamin B complex or vitamin B 12 has been shown to increase the number of Schwann cells and myelinated nerve fibers and the diameter of axons, and thereby promote the regeneration of myelinated nerve fibers and the proliferation of Schwann cells (Lopatina et al., 2011).

Detailed explanation-4: -Methylcobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves and has neuroprotective activity, which promote neurons to function in proper way and thus improves Alzheimer disease, Parkinsonism, Dementia and neuropathic syndromes. It is an approved treatment for peripheral neuropathy.