MRCP UK EXAMINATIONS

Detailed explanation-1: -Distal symmetrical polyneuropathy is the most common variety of neuropathy. The nerve fibers are affected in a length-dependent pattern; toes and soles are affected first and hands later. A majority of these cases occur due to metabolic, toxic or systemic disorders.

Detailed explanation-2: -Definition of Small Fiber Neuropathy A small fiber neuropathy occurs when damage to the peripheral nerves predominantly or entirely affects the small myelinated (A) fibers or unmyelinated C fibers. The specific fiber types involved in this process include both small somatic and autonomic fibers.

Detailed explanation-3: -The most common type of peripheral neuropathy is diabetic neuropathy, caused by a high sugar level and resulting in nerve fiber damage in your legs and feet. Symptoms can range from tingling or numbness in a certain body part to more serious effects, such as burning pain or paralysis.

Detailed explanation-4: -According to our results, QST is the most sensitive test for SFN diagnosis (72% Se, 40% Sp).