MRCP UK EXAMINATIONS

NEUROLOGY

PERIPHERAL NEUROPATHY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Progressive symmetric loss of sensation in the distal lower extremities.(Note:patient asks if tingling in hands, request A1c)
A
Diabetic Polyneuropathy
B
Mononeuropathy
C
Either A or B
D
None of the above
Explanation: 

Detailed explanation-1: -Distal symmetrical polyneuropathy (DSPN) is a serious complication of diabetes associated with significant disability and mortality. Although more than 50% of people with diabetes develop DSPN, its pathogenesis is still relatively unknown.

Detailed explanation-2: -The most common etiology of DSP is diabetes, accounting for 32–53% of cases. Given the high prevalence of neuropathy in the diabetic population, screening tests for neuropathy should be considered.

Detailed explanation-3: -Peripheral neuropathy is the most common form of diabetic neuropathy. Your feet and legs are often affected first, followed by your hands and arms. Possible signs and symptoms of peripheral neuropathy include: Numbness or reduced ability to feel pain or temperature changes, especially in your feet and toes.

Detailed explanation-4: -Distal sensory peripheral neuropathy (DSPN) is characterized pathologically by symmetrical distal-to-proximal axonal degeneration of sensory nerve fibers [4]. Worldwide DSPN prevalence in combination antiretroviral therapy (cART)–naive persons living with HIV (PLWH) varies widely, from as low as 11% to 56% [5, 6].

There is 1 question to complete.