MRCP UK EXAMINATIONS

Detailed explanation-1: -Patients with myelodysplastic syndrome associated with an isolated del(5q) chromosome abnormality who need frequent red blood cell transfusions may be treated with lenalidomide. Lenalidomide is used to lessen the need for red blood cell transfusions.

Detailed explanation-2: -Background. Red blood cell transfusions are critical in burn management. The subsequent iron overload that can occur from this treatment can lead to secondary hemochromatosis with multi-organ damage.

Detailed explanation-3: -If the patient is stable, and there is no acute blood loss, blood transfusion should be withheld in favor of treatment with iron. If oral iron fails, consideration should be given to parenteral iron therapy before blood transfusion. A protocol and facilities for total-dose intravenous iron infusions should be in place.

Detailed explanation-4: -Transfusion iron overload is a major concern in the management of patients with severe anemic syndromes like thalassemia. Because of the close monitoring of iron homeostasis, excess iron from multiple blood transfusions deposits in different organs of the body and causes organ damage.

Detailed explanation-5: -In people with myelodysplastic syndromes that do not respond to medications, transfusions may be needed to help increase red blood cell or platelet levels. They may also be used in people who are receiving medications that may have temporarily reduced the amount of these blood cells.