NEUROLOGY
SURGERY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Leukocyte and platelet count
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BUN and creatinine levels
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Aspartate aminotransferase (AST) and alanine transaminase (ALT) levels
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Hemoglobin and hematocrit
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Detailed explanation-1: -Blood tests. In myelofibrosis, a complete blood count typically shows abnormally low levels of red blood cells, a sign of anemia common in people with myelofibrosis. White blood cell and platelet counts are usually abnormal, too.
Detailed explanation-2: -Hydroxyurea is an oral chemotherapy medication that is used as a “cytoreductive therapy” in myeloproliferative neoplasms (MPNs) to control the number of blood white cells, red cells, platelets, and to reduce spleen size, and phlebotomy requirements. Hydroxyurea works by inhibiting DNA synthesis and causing cell death.
Detailed explanation-3: -In many people, the presenting sign of the disorder is an abnormally enlarged spleen (splenomegaly) that may be detected upon routine examination or low levels of circulating red blood cells. A complete blood count (CBC) may demonstrate low levels of red blood cells or elevated levels of platelets or white blood cells.
Detailed explanation-4: -According to the World Health Organization, essential thrombocytosis can be diagnosed when the platelet count is over 45, 0000 and there is either a Janus kinase 2 (JAK2), Calreticulin (CALR) or myeloproliferative leukemia virus oncogene (MPL) mutation, lacking clonal or reactive causes.