MRCP UK EXAMINATIONS

Detailed explanation-1: -Coagulation: fibrinogen plays a major role in blood clotting along with other procoagulants like thrombin and factor X.

Detailed explanation-2: -Plasminogen (PLG) is the precursor of plasmin, an active serine protease that dissolves the fibrin of blood clots and acts in many other processes such as embryonic development, tissue remodeling, inflammation and tumor invasion (1, 2). Synthesized in the kidney, PLG is found in plasma and many extracellular fluids.

Detailed explanation-3: -Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin-also known as fibrinolysin-as part of the fibrinolytic pathway that breaks down fibrin blood clots. This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond the site of injury.