NEUROLOGY
SURGERY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Results from a defect in the hematopoietic stem cell that differentiates into all myeloid cells
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Arises from a mutation in the myeloid stem cell
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Results from an uncontrolled proliferation of immature cells derived from the lymphoid stem cell
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Derived from a malignant clone of B lymphocytes
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Detailed explanation-1: -Acute lymphocytic leukemia (ALL) is a malignancy of B or T lymphoblasts characterized by uncontrolled proliferation of abnormal, immature lymphocytes and their progenitors which ultimately leads to the replacement of bone marrow elements and other lymphoid organs resulting in a characteristic disease pattern.
Detailed explanation-2: -Acute lymphocytic leukemia occurs when a bone marrow cell develops changes (mutations) in its genetic material or DNA. A cell’s DNA contains the instructions that tell a cell what to do. Normally, the DNA tells the cell to grow at a set rate and to die at a set time.
Detailed explanation-3: -Acute lymphoblastic leukemia (ALL) is a malignant transformation and proliferation of lymphoid progenitor cells in the bone marrow, blood and extramedullary sites.
Detailed explanation-4: -Leukaemia is the uncontrolled proliferation of an abnormal population of cells in the blood. These abnormal cells infiltrate the bone marrow, impeding the production of the remaining normal cells, and invading the blood and other organs.
Detailed explanation-5: -Chronic lymphocytic leukemia occurs when there is uncontrolled proliferation and accumulation in the blood and bone marrow (sometimes also in lymph nodes, spleen and liver) of neoplastically changed lymphocytes-white blood cells. As the disease progresses, the changed lymphocytes displace healthy blood cells.