NEUROLOGY
SURGERY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Results from a defect in the hematopoietic stem cell that differentiates into all myeloid cells
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Arises from a mutation in the myeloid stem cell
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Results from an uncontrolled proliferation of immature cells derived from the lymphoid stem cell
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Derived from a malignant clone of B lymphocytes
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Detailed explanation-1: -Acute myeloid leukaemia (AML) results from a defect in the haematopoietic stem cell that differentiates into which of the following myeloid cells? AML results from a defect in the hematopoietic stem cell that differentiates into all myeloid cells: monocytes, granulocytes, erythrocytes, and platelets.
Detailed explanation-2: -Myeloid stem cells give rise to a second level of lineage-specific CFU cells that go on to produce neutrophils, monocytes, eosinophils, basophils, mast cells, megakaryocytes, and erythrocytes. Monocytes differentiate further into macrophages in peripheral tissue compartments.
Detailed explanation-3: -Hematopoietic stem cells give rise to different types of blood cells, in lines called myeloid and lymphoid.
Detailed explanation-4: -An immature cell that can develop into all types of blood cells, including white blood cells, red blood cells, and platelets.