NEUROLOGY
SURGERY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Results from a defect in the hematopoietic stem cell that differentiates into all myeloid cells
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Arises from a mutation in the myeloid stem cell
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Results from an uncontrolled proliferation of immature cells derived from the lymphoid stem cell
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Derived from a malignant clone of B lymphocytes
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Detailed explanation-1: -Introduction. Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia. It most often arises from a malignant clone of B cells and has a characteristic phenotype. Patients with CLL are variable in how they present, and the condition is variable in its course.
Detailed explanation-2: -An aggressive (fast-growing) type of leukemia (blood cancer) in which too many B-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood. It is the most common type of acute lymphoblastic leukemia (ALL).
Detailed explanation-3: -Chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) is an indolent malignancy characterized by increased production of mature but dysfunctional B lymphocytes.
Detailed explanation-4: -B lymphocytes (also known as B-cells) are specialised white blood cells. Under normal conditions they produce immunoglobulins (also called antibodies) that help protect our bodies against infection and disease. In people with CLL, lymphocytes undergo a malignant (cancerous) change and become leukaemic cells.
Detailed explanation-5: -The exact cause of chronic lymphocytic leukemia is not known. Multiple genetic mutations occur in the DNA of blood-producing cells. These mutations cause the blood cells to produce abnormal lymphocytes, which are not effective at fighting infection. Usually, an abnormal chromosome is present in a patient with CLL.