NEUROLOGY
SURGERY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Results from a defect in the hematopoietic stem cell that differentiates into all myeloid cells
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Arises from a mutation in the myeloid stem cell
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Results from an uncontrolled proliferation of immature cells derived from the lymphoid stem cell
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Derived from a malignant clone of B lymphocytes
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Detailed explanation-1: -Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self-renews, proliferates, and differentiates to give rise to a myeloproliferative disease.
Detailed explanation-2: -Causes. Chronic myeloid leukemia is caused by a rearrangement (translocation ) of genetic material between chromosome 9 and chromosome 22. This translocation, written as t(9; 22), fuses part of the ABL1 gene from chromosome 9 with part of the BCR gene from chromosome 22, creating an abnormal fusion gene called BCR-ABL1.
Detailed explanation-3: -In CML, a genetic change takes place in an early (immature) version of myeloid cells–the cells that make red blood cells, platelets, and most types of white blood cells (except lymphocytes). This change forms an abnormal gene called BCR-ABL, which turns the cell into a CML cell.
Detailed explanation-4: -Abstract. Chronic myelogenous leukemia (CML) originates in a pluripotent hematopoietic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and other hematopoietic cell lineages are involved in the process of clonal proliferation and differentiation.
Detailed explanation-5: -Chronic myeloid leukemia (CML) is a classical example of stem cell cancer since it arises in a multipotent hematopoietic stem cell upon the acquisition of the t(9; 22) chromosomal translocation, that converts it into a leukemic stem cell (LSC).