NEUROLOGY
SURGERY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Chronic use of ____ to reduce gastric acid production can inhibit B12 absorption, as can the use of ____ in managing diabetes.
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Proton pump inhibitors (PPIs), metformin
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Proton pump inhibitors (PPIs), Tresiba
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Proton pump inhibitors (PPIs), humalog
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Proton pump inhibitors (PPIs), antacid
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Explanation:
Detailed explanation-1: -There is general consensus that gastric acid–lowering drugs, including proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs), and the antidiabetes drug metformin can reduce circulating vitamin B-12 concentrations with prolonged use.
Detailed explanation-2: -There was no significant difference in the maximum glucose concentration. In conclusion, concomitant administration of PPIs with metformin significantly increased plasma metformin exposure, but the effects on glucose disposition were minor and varied depending on the PPI administered.
There is 1 question to complete.