NEUROLOGY
SURGERY
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Question
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Describe why the stroma of the bone marrow is important.
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The stroma is important in an indirect manner,
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The stroma is important in an indirect manner, in that it produces the colony-stimulating factors needed for hematopoiesis.
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Iron, vitamin B12, folic acid, pyridoxine, protein, and other factors are required. A deficiency of these factors during erythropoiesis can result in decreased red cell production.
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An increased number of band cells is sometimes called a left shift or shift to the left. A shift to the left indicates that more immature cells are present in the blood than normal.
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Explanation:
Detailed explanation-1: -Stroma. The stroma of the bone marrow includes all tissue not directly involved in the marrow’s primary function of hematopoiesis. Stromal cells may be indirectly involved in hematopoiesis, providing a microenvironment that influences the function and differentiation of hematopoietic cells.
Detailed explanation-2: -Bone marrow stromal cells (SC) play a crucial role in sustaining proliferation, differentiation and self-renewal of hematopoietic stem cells. It is quite possible that adherent cell layers derived from bone marrow support hematopoiesis in liquid culture (21).
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