MRCP UK EXAMINATIONS

NEUROLOGY

SURGERY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
If a bone marrow analysis is performed on a patient with AML, what results are seen?
A
The results will show an excess of immature blast cells, which is the hallmark of the diagnosis.
B
The signs and symptoms result from insufficient production of normal blood cells.
C
The goal of treatment is to obtain remission without excess toxicity and with a rapid hematologic recovery so that additional therapy can be administered if needed.
D
Because the illness is unpredictable.
Explanation: 

Detailed explanation-1: -The percentage of blasts in the bone marrow or blood is particularly important. Having at least 20% blasts in the marrow or blood is generally required for a diagnosis of AML. (In normal bone marrow, the blast count is 5% or less, while the blood usually doesn’t contain any blasts.)

Detailed explanation-2: -Bone marrow biopsy To confirm a diagnosis of AML, a small sample of your bone marrow will be taken to examine under a microscope. This procedure is known as a bone marrow biopsy.

Detailed explanation-3: -The clinical hallmark of CML is the uncontrolled production of mature and maturing granulocytes, predominantly neutrophils, but also basophils and eosinophils.

Detailed explanation-4: -For a diagnosis of AML, a marrow or blood blast count of 20% or more is required, except for AML with t(15; 17), t(8; 21), inv(16) or t(16; 16), and some cases of erythroleukemia. Myeloblasts, monoblasts, and megakaryoblasts are included in the blast count.

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