MRCP UK EXAMINATIONS

NEUROLOGY

SURGERY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
In current tuberculosis (TB) treatment, four first-line medications are used: ____, ____, ____, and ____
A
rifampin, pyrazinamide, ethambutol, isoniazid
B
rifampin, pyrazinamide, ethambutol
C
Tachypnea, dyspnea, mild to moderate hypoxemia
D
Tachypnea, dyspnea, hypoxemia
Explanation: 

Detailed explanation-1: -Of the approved drugs, isoniazid (INH), rifampin (RIF), ethambutol (EMB), and pyrazinamide (PZA) are considered first-line anti-TB drugs and form the core of standard treatment regimens (Figure 6.4) (Table 6.2).

Detailed explanation-2: -First-line agents for treatment of TB disease consist of isoniazid, a rifamycin (rifampin or [less frequently] either rifapentine or rifabutin), pyrazinamide, and ethambutol; in addition, moxifloxacin is a first-line agent when administered in combination with isoniazid, rifapentine, and pyrazinamide [6].

Detailed explanation-3: -The most common treatment for active TB is isoniazid INH in combination with three other drugs-rifampin, pyrazinamide and ethambutol. You may begin to feel better only a few weeks after starting to take the drugs but treating TB takes much longer than other bacterial infections.

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