MRCP UK EXAMINATIONS

Detailed explanation-1: -Leukotriene modifiers, also called leukotriene receptor antagonists, are a group of medications. They can help prevent breathing problems associated with allergies, asthma and chronic obstructive pulmonary disease. Examples include montelukast, zafirlukast and zileuton .

Detailed explanation-2: -Leukotriene modifiers work by blocking the action of leukotrienes, one cause of the inflammation and nasal congestion associated with allergies. For those with allergies and asthma, leukotriene modifiers help keep bronchial tubes, airways to your lungs, from constricting.

Detailed explanation-3: -The leukotriene modifiers can be divided into two pharmacologic categories: the leukotriene receptor antagonists, zafirlukast (ACCOLATE®) and montelukast (SINGULAIR®), and the 5-lipoxygenase inhibitors, zileuton (ZYFLO®) and zileuton extended-release (ZYFLO CR®).

Detailed explanation-4: -There are two types of leukotriene modifier: leukotriene synthesis inhibitors and cysteinyl leukotriene receptor antagonists. Both are used to block the bronchoconstrictor and pro-inflammatory activity of cysteinyl leukotrienes within the asthmatic airway.

Detailed explanation-5: -Montelukast and zafirlukast are cysteinyl leukotriene receptor antagonists indicated to prevent and treat chronic asthma.