MRCP UK EXAMINATIONS

NEUROLOGY

SURGERY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Thalassemia major
A
Megaloblastic anemias
B
Hemolytic anemias
C
Hypoproliferative anemias
D
None of the above
Explanation: 

Detailed explanation-1: -The hallmark is low reticulocyte count, which may be due to bone marrow failure, bone marrow replacement, inflammation, or nutritional deficiencies. Iron deficiency is the most common hypoproliferative anemia, followed by anemia of chronic inflammation and renal disease.

Detailed explanation-2: -If the absolute reticulocyte count is 100, 000 mm3 or higher, the anemia is hyperproliferative type (i.e. hemolytic anemia or anemia of acute blood loss). If it is less than 100, 000 mm3 the anemia is hypoproliferative (iron, B12, or folic deficiency, anemia of chronic disorder etc.).

Detailed explanation-3: -There are only two causes of a hyper-proliferative anemia: bleeding and hemolysis. More commonly, the reticulocyte count is low or inappropriately normal. In this circum-stance, there is a broad differential diagnosis and it is useful to divide such anemias into those associated with a normal bone marrow vs.

Detailed explanation-4: -Anemia of chronic disease (AOCD) Renal failure. Aplastic anemia. Pure red cell aplasia. Myelofibrosis or myelophthisic processes. Multiple myeloma. 08-Aug-2022

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