MRCP UK EXAMINATIONS

Detailed explanation-1: -There are 2 receptors for IgE: the low-affinity IgE receptor (FcRII; CD23) expressed on the surface of B cells, as well as other hematopoietic cells, and the high-affinity IgE receptor (FcR1).

Detailed explanation-2: -What are IgE-mediated food allergies? IgE-mediated food allergies cause your child’s immune system to react abnormally when exposed to one or more specific foods such as milk, egg, wheat or nuts. Children with this type of food allergy will react quickly-within a few minutes to a few hours.

Detailed explanation-3: -The specific IgE produced in response to the allergen binds to the high-affinity receptor for IgE on mast cells, basophils, and activated eosinophils. IgE production can be amplified by these cells because, upon activation, they produce IL-4 and CD40 ligand.

Detailed explanation-4: -Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) “isotype") that has been found only in mammals. IgE is synthesised by plasma cells. Monomers of IgE consist of two heavy chains ( chain) and two light chains, with the chain containing four Ig-like constant domains (C1–C4).