MRCP UK EXAMINATIONS

Detailed explanation-1: -Cytomegalovirus (CMV) retinitis is the most common intra-ocular infection in patients with acquired immune deficiency syndrome (AIDS), and a leading cause of AIDS-related morbidity. Untreated CMV retinitis in AIDS patients is a progressive and potentially blinding disorder.

Detailed explanation-2: -Cytomegalovirus (CMV) is the most common cause of necrotizing retinitis in patients who are HIV positive. Varicella-zoster virus (VZV) and, less commonly, HSV may cause acute retinal necrosis (ARN). This necrotizing retinitis may be unilateral or bilateral.

Detailed explanation-3: -Acquired immunodeficiency syndrome (AIDS)-related cytomegalovirus (CMV) retinitis is one of the most serious ocular complications in individuals with AIDS. It can progress to blindness, and in some cases, be accompanied by potentially fatal systemic disease. It is typically caused by reactivation of latent disease.

Detailed explanation-4: -Cytomegalovirus (CMV) retinitis is a viral eye infection. It can be serious and even cause blindness. You’re more likely to get this infection if you have a weak immune system from HIV or AIDS. CMV retinitis used to be very common among people with HIV before HIV drugs came along in the 1990s.

Detailed explanation-5: -Inflammation. Primary and latent CMV infections induce chronic, systemic type 1 inflammatory responses [7]. Such sustained immune activation can augment alloimmune responses by enhancing the expansion and function of alloreactive T cells after transplantation.