MRCP UK EXAMINATIONS

Detailed explanation-1: -The most conspicuous macrophage populations of the spleen are located in the marginal zone. Strategically positioned in the bloodstream and adorned with unique sets of pattern recognition receptors, they play an important role in host defense by bridging the innate and adaptive immune systems.

Detailed explanation-2: -Localization and phenotype of splenic M subsets. MZMs (in green) are found in the marginal zone (MZ) outer layer – they are also in direct contact with blood-borne particles. These cells express in their surface the molecules MARCO and SIGNR1 and other receptors that help in the uptake of blood-borne pathogens.

Detailed explanation-3: -Spleen autofluorescent cells are macrophages and represent the red pulp macrophages of the spleen. Flow cytometry stainings on monocytes in the spleen, blood monocytes, spleen autofluorescent cells, M-CSF, and GM-CSF cultured monocyte-derived macrophages.

Detailed explanation-4: -The splenic red pulp contains macrophages that serve mostly to filter blood and recycle iron from aging red blood cells.