RESPIRATORY
BRONCHIECTASIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Belongs to the diarylquinoline class
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Targets the rpoB gene encoding the subunit c of the ATP synthase of Mycobacterium tuberculosis
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Binds to the oligomeric and proteolipic subunit c of mycobacterial ATP synthase
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Bedaquiline is rapidly absorbed orally
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Detailed explanation-1: -Bedaquiline targets the subunit of mycobacterial F-ATP synthase.
Detailed explanation-2: -Bedaquiline (BDQ) inhibits ATP generation in Mycobacterium tuberculosis by interfering with the F-ATP synthase activity.
Detailed explanation-3: -Bedaquiline inhibits ATP synthesis of Mycobacterium tuberculosis by binding to Fo of the ATP synthase21, 22. Biochemical and x-ray crystallographic studies indicate that BDQ binds to the c-ring isolated from Mycobacterium phlei23.
Detailed explanation-4: -Conclusions: This study demonstrated that compared with patients who do not receive bedaquiline, this drug has the potential to achieve a higher culture conversion rate and a lower mortality risk among drug-resistant tuberculosis cases.