MRCP UK EXAMINATIONS

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RESPIRATORY

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
(Multiple Choice) Patients with adult chronic obstructive pulmonary disease (COPD) often have elevated PaCO2, which is closely related to the pathological and physiological changes of adult chronic obstructive pulmonary disease. Which of the following statements are correct? ①Patients with high arterial blood PaCO2 have poor alveolar ventilation ②Patients with high PaCO2 are often caused by ventilation/perfusion mismatching ③Panlobular emphysema patients are more likely to develop high PaCO2 ④PaCO2 is inversely proportional to the patient’s breathing work
A
①
B
②
C
③
D
④
Explanation: 

Detailed explanation-1: -The logistic regression analyses proved that PaCO2 was associated with BODE ≥5 in COPD patients (odds ratio = 1.160, 95% CI: 1.025–1.313, = 0.019). Conclusions. A higher level of PaCO2 was associated with a higher index for BODE or GOLD in COPD and had the predictive value for severe COPD.

Detailed explanation-2: -As COPD advances, these patients cannot maintain a normal respiratory exchange. COPD patients have a reduced ability to exhale carbon dioxide adequately, which leads to hypercapnia.

Detailed explanation-3: -Hypercapnia is the increase in partial pressure of carbon dioxide (PaCO2) above 45 mmHg.

Detailed explanation-4: -We found a positive, strong, and statistically significant correlation of 0.82 between PaCO2 and ETCO2 in COPD patients with hypercapnic respiratory failure on mechanical ventilation.

There is 1 question to complete.
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