MRCP UK EXAMINATIONS

RESPIRATORY

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Name of enzymes inhibitor which is deficient in AATD
A
Alpha 1 Antitripsine Deficiency
B
Alkaline Acid
C
Either A or B
D
None of the above
Explanation: 

Detailed explanation-1: -Alpha-1 antitrypsin (AAT) deficiency is a clinically under-recognized genetic disorder that causes the defective production of alpha-1 antitrypsin protein. AAT protein protects the body from the neutrophil elastase enzyme, which is released from white blood cells to fight infection.

Detailed explanation-2: -Alpha-1-antitrypsin (AAT) was first identified as an inhibitor of the proteinase trypsin (and hence its early name) in the 1950’s (1).

Detailed explanation-3: -Definition. Alpha-1 antitrypsin (AAT) deficiency is a condition in which the body does not make enough of AAT, a protein that protects the lungs and liver from damage. The condition can lead to chronic obstructive pulmonary disease (COPD) and liver disease (cirrhosis).

There is 1 question to complete.