RESPIRATORY
CHRONIC OBSTRUCTIVE PULMONARY DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Budesonide and Formoterol
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Tiotropium and Formoterol
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Glycopyrronium and Formoterol
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Beclomethasone and Formoterol
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Detailed explanation-1: -Formoterol (beta(2)-agonist) and tiotropium (anticholinergic) are long-acting bronchodilators with different mechanisms of action. Formoterol has a fast onset and a bronchodilator effect of approximately 12 h, while tiotropium has a 24-h bronchodilator effect and is given once daily.
Detailed explanation-2: -FEV1 is a common measure used to assess lung function and multiple studies show FEV1 declines at a faster rate in smokers compared to non-smokers [5]. Randomised control trials (RCTs) have found that inhaled corticosteroids (ICS) reduce the rate of FEV1 decline in people with COPD [6–9].
Detailed explanation-3: -Tiotropium is in a class of medications called bronchodilators. It works by relaxing and opening the air passages to the lungs to make breathing easier.
Detailed explanation-4: -The GOLD defines acute bronchodilator reversibility as a FEV1 improvement from the predose value by 12% and >200 mL.