MRCP UK EXAMINATIONS

Detailed explanation-1: -What is multidrug-resistant tuberculosis (MDR TB)? Multidrug-resistant TB (MDR TB) is caused by an organism that is resistant to at least isoniazid and rifampin, the two most potent TB drugs. These drugs are used to treat all persons with TB disease.

Detailed explanation-2: -Multidrug-resistant TB (MDR TB) is resistant to more than one anti-TB drug and at least isoniazid (INH) and rifampin (RIF).

Detailed explanation-3: -Isoniazid Resistance Resistance to INH is usually due to a mutation in katG or inhA, and is less commonly due to mutations in other genes, such as the ahpC32 gene40, 41. INH is a prodrug that must be activated by catalase-peroxidase, an enzyme regulated by katG, to be effective against TB.

Detailed explanation-4: -Levofloxacin and moxifloxacin are the two most frequently recommended agents, and the WHO has recommended the use of these drugs for the treatment of MDR-TB.

Detailed explanation-5: -Multidrug-resistant tuberculosis (MDR-TB) is defined as disease due to Mycobacterium tuberculosis that is resistant to isoniazid (H) and rifampicin (R) with or without resistance to other drugs.