MRCP UK EXAMINATIONS

RESPIRATORY

OLD TUBERCULOSIS

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

How is polyresistance defined?

A	Resistant to a first-line anti-TB drug
B	Resistant to more than one first-line anti-TB drug
C	Rifampicin resistant
D	None of the above

Explanation:

Detailed explanation-1: -Drug-resistant TB is caused by TB bacteria that are resistant to at least one first-line anti-TB drug. Multidrug-resistant TB (MDR TB) is resistant to more than one anti-TB drug and at least isoniazid (INH) and rifampin (RIF).

Detailed explanation-2: -Poly-resistance: resistance to more than one first-line anti-TB drug, other than both isoniazid and rifampicin. Multidrug resistance (MDR): resistance to at least both isoniazid and rifampicin.

Detailed explanation-3: -First-line agents for treatment of TB disease consist of isoniazid, a rifamycin (rifampin or [less frequently] either rifapentine or rifabutin), pyrazinamide, and ethambutol; in addition, moxifloxacin is a first-line agent when administered in combination with isoniazid, rifapentine, and pyrazinamide [6].

Detailed explanation-4: -Polydrug resistance: This is when more than one first-line anti-TB drugs (except both isoniazid and rifampicin) fail to work against TB infection. Multidrug resistance (MDR): This is when both isoniazid and rifampicin fail to work against TB infection.

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