MRCP UK EXAMINATIONS

Detailed explanation-1: -What is a Ghon complex? Ghon complex, a radiologically detectable finding characteristic of primary tuberculosis (or TB), was first reported by Anton Ghon, an Austrian pathologist. It refers to the presence of a pulmonary lesion, known as Ghon lesion or Ghon focus, along with ipsilateral hilar lymph node involvement.

Detailed explanation-2: -Ghon’s complex is a lesion seen in the lung that is caused by tuberculosis. The lesions consist of a Ghon focus along with pulmonary lymphadenopathy within a nearby pulmonary lymph node.

Detailed explanation-3: -Primary tuberculosis occurs in previously uninfected individuals with competent immune responses2, 6. The characteristic lesion, a caseating granuloma, is a localized lesion in tissue consisting of a central area of caseous necrosis surrounded by epitheloid macrophages and then lymphocytes, Figure 1.

Detailed explanation-4: -Specifically, in parenchymal pulmonary tuberculosis infection, primary tuberculosis is hallmarked with a pulmonary lesion also known as a Ghon lesion or Ghon focus and affected draining lymph node adenopathy forming the Ghon’s complex (see Figure 1) 1.