MRCP UK EXAMINATIONS

Detailed explanation-1: -TB meningitis is often described in three stages, but patients don’t necessarily progress from one stage to the next in an orderly fashion. Stage 1 is considered alert, stage 2 is lethargy, and stage 3 is coma.

Detailed explanation-2: -Meningitis is the most deadly form of TB, particularly in persons coinfected with HIV. Early diagnosis and treatment can dramatically reduce the high mortality associated with this disease. In general, treatment should be at least nine months in duration and should be comprised of at least four agents to which the M.

Detailed explanation-3: -The best antimicrobial agents in the treatment of tuberculous meningitis (TBM) include isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and streptomycin (SM), all of which enter cerebrospinal fluid (CSF) readily in the presence of meningeal inflammation.

Detailed explanation-4: -The WHO guidelines recommend a first-line regimen of 2 months of isoniazid, rifampicin, pyrazinamide, and ethambutol (children) or streptomycin (adults) followed by 10 months of isoniazid and rifampicin.