Pregnancy. Although isoniazid and rifampicin cross the placental barrier, they have not been associated with teratogenic effects; only the use of ............... should be avoided because it is ototoxic to the fetus.

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

Pregnancy. Although isoniazid and rifampicin cross the placental barrier, they have not been associated with teratogenic effects; only the use of ____________ should be avoided because it is ototoxic to the fetus.

A	ethambutol
B	Streptomycin
C	rifampicin
D	piraji tears

Explanation:

Detailed explanation-1: -Streptomycin should not be used because it has been shown to have harmful effects on the fetus. Pyrazinamide (PZA) is not recommended to be used because its effect on the fetus is unknown.

Detailed explanation-2: -Streptomycin and kanamycin are associated with eighth cranial nerve damage and should be avoided if possible during cyesis. At least five of these compounds have documented evidence of transplacental passage.

Detailed explanation-3: -All 4 first line drugs [isoniazid, rifampicin (rifampin), ethambutol and pyrazinamide] have an excellent safety record in pregnancy and are not associated with human fetal malformations.

Detailed explanation-4: -Streptomycin should be avoided in pregnancy because it can damage the fetal VIII cranial nerve (responsible for hearing and balance).

There is 1 question to complete.

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