MRCP UK EXAMINATIONS

RESPIRATORY

OLD TUBERCULOSIS

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

What factors are involved in the pathogenesis of man-man contagion of TB?

A	Number of viable bacilli in sputum and concentration in air
B	FACING
C	host susceptibility
D	aerosolization of droplets with cough

Explanation:

Detailed explanation-1: -Transmission of TB is by inhalation of infectious droplet nuclei containing viable bacilli (aerosol spread). Mycobacteria-laden droplet nuclei are formed when a patient with active pulmonary TB coughs and can remain suspended in the air for several hours. Sneezing or singing may also expel bacilli.

Detailed explanation-2: -Close contacts of a person with infectious TB disease. Persons who have immigrated from areas of the world with high rates of TB. Children less than 5 years of age who have a positive TB test. Groups with high rates of TB transmission, such as homeless persons, injection drug users, and persons with HIV infection.

Detailed explanation-3: -TB infection happens in 4 stages: the initial macrophage response, the growth stage, the immune control stage, and the lung cavitation stage. These four stages happen over roughly one month.

Detailed explanation-4: -Genomic analysis of M. tuberculosis revealed the presence of two tyrosine phosphatase genes–mptpA (Rv2234) and mptpB (Rv0153c). We have characterized both the tyrosine phosphatases of M. tuberculosis.

There is 1 question to complete.