MRCP UK EXAMINATIONS

RESPIRATORY

PULMONOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
In pleural fluid:protein in fluid 2, protein in serum 4.4 ____ LDH in fluid = 160 LDH in serum 430 Which of the following is least suitable for the differential diagnosis?
A
Heart failure
B
lupus erythematosus SLE.
C
Cirrhosis of the liver
D
Renal failure
Explanation: 

Detailed explanation-1: -Pleural fluid lactate dehydrogenase LDH is a marker of inflammation or cellular injury, so is a sensitive, but non-specific pathological marker. LDH levels of greater than three times the upper limit of normal (often >1, 000 U/L) are often indicative of pleural infection, in the appropriate clinical scenario.

Detailed explanation-2: -The median ADA value of pleural fluid was 36.50U/l (24.50) in TBP group and 15U/l (21) in the PPE group. The ADA value was statistically significantly higher in the TBP group (P<0.001). The median values of pleural fluid LDH/ADA ratio in TBP and PPE groups were 16.10 (12.53) and 32.90 (34.45), respectively.

Detailed explanation-3: -Normal pleural fluid Protein: < 2% (1-2 g/dL) White blood cells (WBC): < 1000/mm³ Glucose: similar to that of plasma. LDH: <50% plasma concentration.

Detailed explanation-4: -Pleural fluid/serum protein ratio. Pleural fluid LDH/upper limit of normal serum LDH (240 IU/L in our institution).

There is 1 question to complete.